If it's a science-related job my guess would be you'd have virtually no chance of changing from the inside (although that's a worthy goal).
One consideration might be how this would affect your future career. It may be a great plan to take a well paid job at this stage, but what autonomy would it offer you (plus career development)? Would working for the company make it difficult to be taken seriously (or viewed professionally) if you decided to quit and move into another field?
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